OnChainDNA (NFT TRADING APPLICATION FOR DNA)

This project will use the transaction payloads to enable NFT trades in limited sequence information space between users as part of a subnet consortium that seeks to aggregate consumer DNA data.

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About

The human DNA blockchain marketplace is made up of about a dozen companies that do not yet have enough consumer participants (each chain has about 1k users) to interest significant and ongoing purchases of data. An avalancheavax subnet could enable these multiple blockchains to aggregate their user's data and these could be traded to researchers and pharmacists as NFTs given the inclusion of 1024 bytes of payload data along with transfer of such tokens. This project will show the feasibility of such a transactional environment for trade in small portions of DNA sequence space by sorting DNA sequences into sequence groups relatively centered around known single nucleotide polymorphisms so as to establish valuable classes of mutation contexts for medically justified research and development.

Problem

In order to improve the study and the research on health care industry, the researchers need to gather people's DNA sequences as much as possible to help them to find better treatments and cures for diseases. The researchers struggle to get the newest and updated human DNA on time. Patients are preferred to choose personalized medicine, so stored DNA tokens are their simple and convenient way to get their prescription.

Goal

This project is set up to show that small amounts of the sequences can be sent and received easily and cheaply. It secures and protects the DNA providers' sequences. It helps patients to get personalized medicines and also anonymously provides the data to medical researchers.

Users

  1. Medical experts/specialists who need small amounts of the DNA to do research and data collections.
  2. Biology tech companies who need DNA trade info and DNA blockchain to improve health care system and industry.
  3. Patients and healthy conditioned person who are interested in DNA blockchain to use the platform to share their DNA to get personalized drugs and contribute their DNA data to the medical industry.
  4. Biology learner who are interests to learn and trade.

Solution

This will be a simple DNA trading platform for patients and medical researchers.

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Updates

posted an update —

The team met via Zoom and set up a discord server and github repository on 10_9_20. There was some interest in expanding the project beyond the X-chain. We are still looking for a couple of new members to allow for this kind of expansion. Tasks for next week were set out and a next meeting time was set up.

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posted an update —

Avalanche NFTs for gene families associated with specific diseases.

Diseases can be found to correlate with mutations in one or more genes. In some instances many gene mutations are associated with a particular disease phenotype. In the case of the inherited cardiovascular disease HCM (hypertrophic cardiomyopathy) 400 mutations in 13 genes have been found in patients suffering from such a disorder. The unique structure of Avalanche NFTs provides an architecture on which these gene regions of a person’s DNA could be fragmented and grouped into a family of non-fungible tokens that when aggregated across many individuals could provide a marketplace from which researchers could purchase this data for further development and analysis. By fragmenting the sequence information into already known familes of mutations for a specific diseases it is possible to enable the sale of data without having to buy the entire sequence. The ability to append 1024 bytes of arbitrary data to the transaction enables the transfer of the sequence information along with the purchase of individual NFTs. The structure and function of Avalanche NFT operational properties is ideally suited to make trade in disease associated mutations economically viable since hosting of such transactions on a subnet marketplace could allow disparate blockchains to interoperate by aggregating their consumer DNA data on a piecemeal basis. This project demonstrates the feasibility of such a marketplace for NFTs of defective DNAs.

A person chooses to have their DNA analyszed for the presence of mutations associated with a particular disease.

~1024 bytes of DNA sequence data around each of these genes is identified and isolated.

The DNA owner chooses how many of their genes per disease analyzed that they would like made into NFTs ( some genes’ mutations contribute more to particular disease outcomes than others, this information will be displayed to help in decision making.)

Those data are converted via the program CB58ref into payloads for inclusion with the NFT including description data of the genes identified.

The disease family is produced and receives a three or four letter ticker (here HCM).

Then dependent on the number of genes selected that number of groups are produced.

Finally, the DNA owner decides how many of the NFTs they would like make based on how many they expect to be able to sell. These NFTs are then produced.

The information on these available NFTs are displayed on the marketplace interface and these can then be purchased by another user of the system.

The marketplace will include the number of diseases, individuals, and genes per individual with mutations that are available for sale. A special sorting algorithm will enable a researcher to search for all mutations of disease x, from individual y, and genes z.

The purchase includes the transmittal of the sequence information as a payload which using the UTXO outputs will be decoded back into the DNA sequence and descriptive information. These data will be available as single directory for download by the purchasers. The DNA owner receives a fee in this demonstration set at 1 AVAX per NFT. Later designs will include functionality for price negotiation between buyers and sellers.

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posted an update —

Made NFTs on @Avalancheavax 's Fuji testnet using Cardona's tutorial https://docs.avax.network/v1.0/en/tutorials/non-fungible-token-pt-1/ and utilizing Moreati's python program https://t.co/ly8B56bVES to construct the payload of an NFTDNA called DNAX representing a portion of the fly gene when over-expressed develops a leg where the antenna was.... This was a test to see how the representation of DNA data can be sent and recieved. https://discordapp.com/channels/578992315641626624/704357488627286148/761749441086357525

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