Extract from T.V. Raman's book Auditory User Interfaces about shortcomings of using screen readers with GUIs:
"Though often cited as an advantage of the screen-reading approach, producing spoken output without any help from the user application causes the screen-reading paradigm to break down when confronted with more and more complex visual displays. Rich visual interfaces enable application designers to produce complex dialogues that exploit the power of the visual mode of interaction. The meaning and intent of such dialogues is often represented implicitly in the visual layout, rather than explicitly in the form of text appearing on the screen. A screen-reading program attempting to meaningfully speak these displayed dialogues very quickly runs into the impedance mismatch described in Sec. 1.3. Even when the screen-reading application succeeds in truthfully speaking the entire displayed content, the listener is stilI left to guess at the meaning and intent. Thus, as visual interfaces have evolved into more and more complex interactions, the corresponding access solutions based on retrofitting speech output have lagged further and further behind. As a case in point, the World Wide Web (WWW) is only partially accessible using today's screen-reading applications. Thus, the primary shortcoming with screen-readers is their inability to convey the meaning and structure present in visually displayed information."
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