## Inspiration

One of the major paths for spreading and transmission of infectious diseases is represented by the oral cavity. Furthermore, a source that infects the oral cavity is represented by the gingival area around the natural teeth - especially those with dental restorations. These aspects are important in the existing global health crisis / coronavirus COVID-19 pandemic.

## What it does

The aim of our study is to develop/to detect the best surface treatment methods for different dental restorative materials, in order to improve physiologic cell adhesion of gingival epithelial tissue on these materials, thus blocking an important path for transmitting oral infections.

## How I built it

The objectives of our study are as follows:

  • to detect the way different surface treatments of dental restorative materials can improve gingival physiological adhesion;
  • to study / to develop diverse in vitro methods to evaluate gingival adhesion that correspond to different dental restorative materials;
  • to study / to develop diverse in vivo methods to evaluate gingival adhesion that correspond to different dental restorative materials.

In the present study, we focus on materials such as:

  • zirconia, Cr-Co alloys, dental ceramics, titanium, titanium alloys etc, as well as
  • PMMA (Poly methyl methacrylate) and 3D printed materials for temporary prosthetic restorations.

Regarding the surface modifications of the proposed studied materials, we hereby include:

  • mechanical abrasion (i.e. air-borne abrasion with fine or coarse alumina particles; grinding and polishing by means of different protocols or systems, glazing etc);
  • electrochemical treatments;
  • laser and plasma treatments;
  • chemically treated surfaces with different reagents;
  • bio-functionalization of surfaces (i.e. poly-dopamine / PDA coating);
  • surface coatings used as carriers etc.

Concerning the in vitro methods to estimate gingival adhesion, we intend to study the biochemical interactions of these materials with the gingival tissue, by analysing specific cell cultures, cell attachment and cell adhesion molecules.

Regarding the diverse in vivo methods to estimate gingival adhesion that correspond to different dental restorative materials, we intend to use image analysis methods in order to appreciate the level of soft tissue integration and its response on photographs possibly taken under the operating microscope.

Regarding the surface modifications of the proposed studied materials, as well as the for the diverse in vitro or in vivo methods to evaluate gingival adhesion that correspond to different dental restorative materials we seek for expertise / advise / collaboration / support.

## Challenges I ran into

Obtaining optimal adhesion of gingival tissues on dental restorative materials.

## Accomplishments that I'm proud of

The materials included in this study are available in our country. Already confirmed collaboration with Romanian specialists in Biochemistry and Material science.

## What I learned

In the context of pandemic crisis, scientific research is of a great benefit.

## What's next for SURFACE TREATMENT OF DENTAL MATERIALS FOR GINGIVAL ADHESION

We expect to detect / to develop best surface treatment methods for different dental restorative materials that improve the gingival seal and reduce the bacterial gingival colonization, therefore, preventing the spreading of infectious diseases via oral environment.

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Updates

posted an update

hello! we seek for expertise / colaboration in the domaines of: surface modifications of dental materials (mechanical treatments, electrochemical treatments, laser & plasma treatments, biofunctionalization of surfaces...), biochemical interactions of dental materials with the gingival tissue (cell cultures, cell attachment and cell adhesion molecules), as well as in image analysis methods (in order to appreciate the level of soft tissue integration and its response on photographs possibly taken under the operating dental microscope)

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