OZONETHERAPY USE AGAINST COVID19 AND IN WELLBEING OF ELDERLY

EVALUATION OF THE USE OF A NEW METHOD OF THERAPY FARMACOIMMUNOCEUTICA (O2O3) TO COUNTERACT THE PROGRESSION OF COVID-INFECTION19 AND RESTORE THE CORRECT IMMUNOLOGICAL RESPONSE IN PATIENTS THROUGH THE CONTROL OF ENDOGENOUS MECHANISMS OF IMMUNOREGULATION AND ESPECIALLY THE CELLULAR AND MITOCHONDRIAL MOLECULAR MECHANISMS FUNDAMENTAL TO COUNTERACT INFECTION AND BLOCK ENDOGENOUS RECEPTORS THAT PROMOTE THE GROWTH OF COVID-19 IN AN INFECTED BODY.

For more than 100 years, ozone, considered a virus killer in nature, has been widely used by people for disinfection, sterilization, deodorization, detoxification, storage, and bleaching due to its strong oxidablity. And for this reason, ozone should be adopted as a weapon in the global fight against COVID-19. The OXYGEN OZONE THERAPY, which despite the enormous scientific literature in its favor, is not yet considered in its true potential, turns out to be a very ancient practice and now also studied and validated. It is useful to treat and cure COVID positive patients by treating them by autoemoinfusion of their blood treated with oxygen ozone at a specific concentration. In Germany, Switzerland and other countries, as well as in Italy, it is a common medical practice for many pathological conditions and diseases. But in history, it has saved thousands of lives in war (especially it has been used by Germans for infected wounds in the pre-antibiotic era) and in Africa and Cuba etc... In China, they have done research immediately and now consider it a potential weapon against CORONAVIRUS. http://www.china.org.cn/opinion/2020-02/26/content_75747237.htm Ozone: A powerful weapon to combat COVID-19 outbreak This project was born in the light of current experimental and clinical knowledge related to the development of COVID-19 infection and physiological biological mechanisms of self-control and new information on the mechanism of action of oxygen ozone therapy. In other words, we have identified the SPIKE and ACE2 cellular receptors that would promote the proliferation of COVID-19 and it is known that these receptors can be blocked with some specific monoclonal but also through the control of NRF2 that blocks the activity of SPIKE and ACE2. Since O2O3 acts on NRF2, it seems very likely that this is the most important physiological mechanism to stimulate to block the endogenous reduplication of COVID-19 by preventing contact with putative receptors of SARS-COVID-19. Treatment with O2O3 has already been tested in many other situations and appears rapid, safe, economical, repeatable and effective. And it has a lot of literature in its favor. Also used and studied by Chinese researchers. Many Hospitals in Italy use Oxygen Ozone to treat Covid19 positive patients. In Bergamo they observed a great improvement after 5 days of treatment (instead of 15 days) and in Udine Hospital ICU only 1 patient out of 36 is intubated. We would like to propose to treat COVID+ patients by reinfusing their own blood, after contact with oxygen ozone (O2O3). Treatment with O2O3 is in addition to standard therapy in ICU patients suffering from COVID pnaemonitis. We will monitor the effect of O2O3 on the Cytokinic Storm, on the Nrf2 and NFKB and NLRP3 inflammasome and on TOLL LIKE RECEPTOR and APC receptors modulation, and on complement and coagulation cascade. We would like to verify the virucidal action of O2O3 and effect of O2O3 therapy on SPIKE and ACE2 receptors and in the prevention of the need for intubation in treated patients and/or to improve the recovery time of patients based on initial positive experiences. A statistical analysis will be carried out on the data and the topic will also be treated in a pharmaco-economic perspective, in order to evaluate the aspect connected with the cost/benefit analysis of the treatment. Inspiration

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Aims OBJECTIV: The purpose of our work was to verify the effectiveness of O2O3treatment on the cognitivity and quality of life of patients with cognitive deficits and Alzheimer’s. OxygenOzoneTherapy is used in medicine since the end of the 19th century for its antibacterial and anti-inflammatory and analgesic effects. Oxygenozonetherapy induces a controlled oxidative stress with a molecular biochemical nuclear action with a reduction of ROS and an increase of the whole antioxidant physiological system (ARE). Studies with NIRS and PET of the brain and fRMN showed an improvement in the brain microcirculation and a reactivation of many hypoperfuse zones of the brain after therapy with systemic oxygenozonetherapy. Methods METHODS: we trated 50 patients suffering from MCI with O2O3 therapy. We treated our patients with an autohemoinfusion of their blood treated with oxygenozone and we measured the quality of life and cognition using specific scales. Results RESULTS: Our experience in 50 MCI patients with MCI has shown a marked improvement in MMSE by an average of four points and cognitivity compared to untreated Pts. Also improved autonomy and spatial orientation and sleep with disappearance of sleep disorders and improved relationship with caregiver. For this reason, the Italian Ministry of Health has approved the treatment with O2O3 in cognitive deficiency and we propose to extend this treatment not expensive, feasible, free from complications in dementia patients. Conclusions O2O3therapy is safe and effective causing the activation of Nrf2 increasing ARE lowering Nfkb. Inhibits the production of APP/aβ in the brain and improves cognitivity in a transgenic mouse (2019).

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