The nascent disciplines of NanoToxicology and NanoPathology are dense harvesting fields of Unknown Unknowns. Computational modeling pushes back these investigative frontiers through the quickening processes of predictive modules development. In silico techniques take verifiable, virtual leaps between the lacunae of resource-intensive lab work, clinical trial protocols, and the long, laborious establishment of new endpoints in nanosafety standards. Computational NanoToxicology disrupts the discourse on nanorisk evaluation and assessment and reveals through model-driven discovery the clearest way forwards amongst dense and dirty data. DeepMed Library is of the belief that an innovative approach to the scientific literature will play a positively unpredictable role in the design, construction, and maintenance of NanoTox knowledgebases. Looking at the literature differently means that research will be conducted differently, influencing clinical outcomes. NANOTOX MDD™ is DeepMed’s first and modest attempt at model-driven search discovery implementations devised to propel new paradigms in nanotoxicological investigations. It employs a “less with finesse” approach to query through customized filtering factors delimited by 10 computational modelling techniques, rendering highly-refined, wholly relevant in silico search results. Currently a tool in alpha phase, NANOTOX MDD™ is one of several within an evolving portfolio conceived to be released as indispensable nanobiomedical research supports to be utilized as knowledge accelerants, moving forward by orders of magnitude the development, setting, and harmonization of new nanorisk protocols in human and animal health and environmental nanotoxicity standardisations. Searches by modelling technologies [Nano-PBPK, Nano-QSAR/QSPR, Nano-PBPK/PD, QNAR, Nano-QM/MM, QNTR, Nano-QSAR, NANOQSAR/QNTR, Nano-QSPR, SBPKPD], further refined by other filter factors yield most efficient query results, sending researchers back to the labs rather than the library stacks.