I'm Oğuzhan Koyuncu, MD as an Internal Medicine resident in Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty in Turkey. I have an idea about inhaler Covid19 Immunglobulin therapy and a vaccine theory. FDA approved the plasma exchange from one cured person to other COVID19 patient, and IV plasma exchange has lot of potential side effects and not easily to use in routine practice. So, why won't we extract the Ig's of cured patients or with autologically and give them to the patients in Inhaler way? It's more target-specific , less volume is used, easy to deliver it .I have 2 different delivery approaches right now, there are commercially available 2 small machines . Also this method can be used prophylactically. But I don't know how to extract Ig's from blood and put them in a liquid form to nebulization machine or in dry powder state.
So, I need help about: Extracting Ig's from blood (I'm open for another solutions if possible) Making Immunglobulins appropiate to deliver inhaler way
About vaccine, I researched that novel coronavirus attaches our body with Spike (S) proteins, and this proteins are in a group called type 1 fusion proteins of viruses. So, can we deliver a "cocktail" of type 1 fusion proteins ( e.g. influenzavirus, other coronaviridae, and any other less contagious pathogens) and expect a "cross-recognition" with delivering them against novel coronavirus? I'm open for any other vaccine opportunities also.
Here are my references about delivery of inhaler Immunglobulins: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1057-3 https://doi.org/10.1016/j.pharma.2018.03.003