During the COVID-19 pandemic, there is a severe lack of medical devices, especially ventilators. The common till now procedure of building a new ventilator from the very beginning is not the solution to this problem, as it is a time-consuming procedure not applicable for quick large-scale production.

Unique Solution

In order to face this pandemic and protect citizens and the economy itself, our team is working on designing, testing and making a new multipatch medical ventilator, the Transformer Ventilator. We propose this unique medical device, which is designed with NURBS and tested with the novel isogeometric analysis (the evolution and powerful generalization of the traditional finite element analysis) using the new pioneering Geomiso software, the world’s first 3D design and isogeometric analysis software, while it is built with existing components from other industries, like the aeronautics, automobile and diving industries to enable large-scale quick production. The uniqueness stems from the fact that we can create a sustainable ventilator at any need, while the comparative advantage is that we can disassemble the ventilator to its components (patches), which can be used for every other medical device.

In geometry modeling with the Geomiso software, parts of the ventilator are simulated separately using a single patch. The discretized NURBS model is decomposed into patches, subdomains with the same material and geometry type. Each parent patch may contain subsidiary patches, consisted of finite elements, where continuity is attained across their interfaces. These domains can be handled quite easily by using multiple patches. A multipatch model of this new ventilator consists of more than 100 patches. We present indicatively 10 of them (see available figures). Patch 1 depicts a breathing (patient) circuit (existing component from diving industry), patch 2 a part of an one-way valve for breathing purposes (automobile industry), patch 3 a part connecting mask and tube for lungs (diving industry), patch 4 an active humidifier (aeronautics industry), patch 5 a manual/mechanical ACD-CPR (aeronautics industry), patch 6 an air inlet and pressure release valve (automobile industry), patch 7 an endotracheal tube (diving industry), patch 8 an oscilloscope (aeronautics industry), patch 9 a nasogastric tube (automobile industry) and patch 10 an oxygen cylinder (diving industry).

The Geomiso Team

The Geomiso team began as a research team in 2010 specialized in isogeometric analysis and evolved into a startup in 2017. Its founder, Panagiotis Karakitsios (, is a world expert in isogeometric analysis with numerous (more than 28) honorary distinctions for his academic and entrepreneurial achievements. He has excellent knowledge of the market and a multiyear experience in business and startups.

During this decade, the team has received numerous distinctions and awards, such as The Gianna Angelopoulos Programme for Science, Technology and Innovation 2019 at Cambridge University, Envolve Award Greece 2018 (first winner, first social media award as the most popular startup), 2017 IEEE IST Best Paper Award, Honorary Distinction in the First Panhellenic Athens Startup Awards Competition 2017, seed funding from Angelopoulos 100, Honorary Distinction in the 3rd Applied Research & Innovation «Greece Innovates!» 2015 from Eurobank and Hellenic Federation of Enterprises, Angelopoulos Continuation Grant 2016, Award and Honorary Distinction by the Athens Chamber of Commerce and Industry 2015, first award as the best startup in the Athens Startup Business Incubator, 5th Award in the 5th Panhellenic Competition i-bank «Innovation &Technology» 2015 from the National Bank of Greece, Angelopoulos Clinton Global Initiative University Fellowship 2015 from President Bill Clinton and Ambassador Gianna Angelopoulos Daskalaki and First Award in the First Panhellenic Youth Entrepreneurship & Innovation Competition «ideatree» 2014. The Geomiso research (four research projects of total budget 790.000,00 €, creation of the Geomiso software) have been co‐financed by the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE.

The Geomiso company has created the world’s first «two in one» isogeometric analysis and 3D design software (disruptive innovation, ten-year applied research, 2010-2019), which manages to fully integrate Computer-Aided Design (CAD) and Computer-Aided Engineering (CAE), thus satisfying the rising need for software of dual CAD/CAE nature in the international market. Innovation stems from the new isogeometric method, the evolution and powerful generalization of the traditional finite element method. The startup ( develops, markets and supports 3D design and engineering simulation software used to design products and predict how they will behave in real-world environments, without having to build test products or conduct crash tests. This is the world’s first two-in-one 3D design and isogeometric analysis software, which merges computer-aided design with computer-aided engineering into a single procedure, thus empowering engineers and industries to deliver faster more accurate results with no geometric errors.

The first version of Geomiso offers linear static NURBS-based isogeometric analysis. The second version provides T-spline-based nonlinear isogeometric analysis for predicting the nonlinear material behavior beyond the yield point (plastic zone), while there is provision for analyzing domains with multiple NURBS patches. NURBS has enjoyed wide popularity worldwide, as can exactly construct any conic section. NURBS-based isogeometric analysis is very well suited for computational analysis, leading to more accurate results in comparison with standard finite elements based on Lagrange polynomials. NURBS accurately represent any conic section, while T-splines ensure watertight connection between patches. As a result, the Geomiso software is ready to be used by the R&D departments (companies, industries) to design, test and make anything. It’s worth mentioning that material non-linearity in combination with the new isogeometric method has attracted increasing attention from both industries and academia during the last decade, modern T-splines accurately design any geometry and exhibit local refinement properties, while the subdomain method allows the analysis of demanding multi-patch models. These new capabilities enable Geomiso to fully integrate the industrial design of any product and its computational real-time testing.

Business Plan

According to business plan, the profit can come from both the blueprint and the final product. The first scenario can be implemented directly, while the second needs extra funding. Novelty stems from both the code of the Geomiso software and the hardware designs. The technical prototype is almost done and can be easily turned into a ready to use product, while the isogeometric analysis with the new Geomiso software shows that it works well.

Our Vision

Our team aspires to make a difference in the fight against COVID-19. The «Transformer Ventilator» aims to contribute to flatten the death curve and support healthcare systems on the COVID-19 crisis worldwide and especially in Europe, where the situation is dramatically critical. It is important to notice that in European countries, such as Italy, the severe lack of ventilators lead to hundreds of deaths in daily basis. The implementation of this project will allow the large-scale production of more efficient ventilators with huge impact to society, as it can save the life of thousands or even millions of people. This problem remains unsolved till now. In this pandemic, European scientists must be all connected and unite in a global approach to fighting COVID-19.

Built With

  • 3d-design
  • aeronautics
  • automobile
  • b-splines
  • c#
  • c++
  • finite-element-analysis
  • geomiso
  • isogeometric-analysis
  • matlab
  • multipatch-geometries
  • nurbs
  • opengl
  • python
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