What's next: The "Glymphatic" Revolution Our findings regarding TOMM40 (a mitochondrial regulator) have led us to a new hypothesis: Alzheimer's is not just a protein problem; it is a bio-energetic plumbing failure. We believe the mitochondrial dysfunction flagged by GenoVision-AD leads to a failure of the Glymphatic System (the brain's waste clearance network). Our next phase will move from "Detection" to "Prediction" by integrating a third data stream: Digital Biomarkers (Wearables). The Concept: By correlating Slow-Wave Sleep data (from Oura/Apple Watch) with our MRI Atrophy maps, we can calculate a "Glymphatic Clearance Score." The Goal: To identify "Super-Agers"—people with high genetic risk (APOE-e4) who remain healthy because their "neural plumbing" is efficient. The Impact: Moving from treating the symptom (Amyloid) to fixing the system (Clearance), potentially solving the "Energy Crisis" of the brain.
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