Prompt

  • These criteria place the developed project against the sphere of biomedical advancements present today - Submissions with well-balanced creativity and usefulness will be given high marks in this category.

Title of Project

The title of this project is Biomed with COVID-19! We have written our proposal, abstract, conducted database research for COVID-19 tests, and provided resources to the community about plasma blood donation centers.

Features

COVID-19 live data, High tech solutions, Models COVID-19 testing in US, Plasma blood donation center information

Abstract

Due to the inconsistencies in antibody levels after patients are diagnosed with COVID-19, the proposed solution intends to create modelling software in python to diagnose fluctuations of antibody levels within individuals to determine potential patterns in the data. Open source data sets will be used in creating a visualizer of COVID-19 trends, such as whether having lower antibody levels is correlated with a risk of becoming reinfected with COVID-19. The model will input data from individuals that stem from a variety of backgrounds to search for a common trend. The biomedical analysis model will be accessible to the general public through a website designed with a user-friendly interface. In addition to the model, the website will include resources such as COVID-19 details about testing sites, current developments in the field, and information on plasma donations. The website will holistically prove users with vital information and updates on COVID-19 while utilizing a biomedical diagnostic model to accumulate more information on possible trends of antibody levels.

Proposal

COVID-19 is a viral infection that has rapidly spread across the globe, causing major uproar and an influx of infected patients to hospitals. COVID-19 is caused by the SARS-CoV-2 virus which operates by injecting its RNA into the host cell. It opens up the risk of respiratory tract infection, causing severely infected people to receive help via ventilators. The symptoms of Coronavirus are versatile and inconsistent, there seems to be no clear-cut reason why some show more symptoms than others, and research for a vaccine is currently underway. However, individuals who have recovered from COVID-19 have antibodies inhibiting the spike protein from targeting more cells. Plasma in the bloodstream can contain these antibodies, allowing blood transfusions to help people build up immunity. A biomedical analysis software was developed to correlate the level of antibodies in a person’s plasma as a function of time based on the severity of their illness and age group. Diminishing antibody levels may also put patients at risk of reinfection (https://www.medrxiv.org/content/10.1101/2020.09.22.20192443v1). Therefore, the software may be used as a diagnostic tool to suggest what individuals are more likely to become infected again.

We created a COVID-19 visualizer to show the total COVID-19 tests over time. We used open source data from Our World In Data to create the chart (https://ourworldindata.org/grapher/full-list-total-tests-for-covid-19?time=2020-02-20..latest) using java and node.js in the backend. In the future, we plan to include a visualizer that lists the typical healthy antibody levels in relation to antibody levels for patients recovering from COVID-19. We will find a database with the concentration of antibodies in plasma for IgG and IgM as they diminish over time. We can expand this to include different age groups, so viewers can compare themselves to data points on the graph in order to see if they can donate their plasma or if their decreasing antibodies puts them at risk of infection. Currently, we have a graph representing the current tests in the United States. This includes both serology and PCR tests. We can expand upon our idea to distinguish the serology from the PCR tests and include other countries to show testing disparities.

The software is used as a diagnostic tool to determine if the lockdown should continue. As tests rise, healthcare officials can gauge how much more PPE and testing equipment/supplies they need. Additionally, we can include the precautions one must take based on the number of tests in the country. If there is a sharp increase in tests, we can further develop the model to update the website with more stringent protocols to follow during the lockdown. If adapted as a phone app, a sharp increase in testing could send users an alert to follow social distancing, wear masks, and stay safe. This update could also include a reminder about getting tested if you or any of your family members goes near a testing center with a high number of tests. These adaptations will allow this COVID-19 tracker to positively affect users and help them stay safe during the pandemic. As the software continues to update, we plan on including more visualizations including: number of positive cases over time, number of fatalities over time, and international travel over time.

When completed, the COVID-19 software will be monumental in describing and solidifying the effects of the virus. We should all be reminded of the frailty and danger of the situation so we continue to value the tight measures set in place to keep everyone safe.

The inspiration behind Project/What led to this project?

During this pandemic, we noticed that people looked at different sources of information to learn about COVID-19 statistics. People who have recovered from the virus may want to compare their antibody levels to others. We began to think of solutions to these issues: people can go to one website that compiles and shows information about when people might have a risk of reinfection due to low antibody levels or donate their plasma after recovery. That is how we thought of COVID-19 with Biomed! Since it is in its early stages, we have the US COVID-19 testing visualizer but still need to input a visualizer based on the data from IgG and IgM antibody levels.

Short Description and What Does our Project Try to Solve?

We are making a Biomedical Analysis Model for antibody levels in COVID-19 patients. It provides statistics, information, and healthy practices through an interactive website and visualizer. Additionally, it will provide information about antibody concentrations in plasma and redirect people with a sufficient level of antibodies to donate blood to others for antibody protection. For example, users will be directed towards plasma donation websites (such as hospitals), and they will also get a live data representative of COVID-19. This solution tries to solve the inconsistencies in information and provide a pool of blood donors for individuals struggling with COVID-19.

Brief Description of Project

COVID-19 with Biomed! provides people with information about the current pandemic and helps users understand how to limit the spread of disease. It provides a biomedical engineering model and information about plasma, blood donations, and testing in the US.

How does your project give a positive impact on society? Benefits?

Biomed with COVID-19! provides people with information that can help them practice safe behaviors during this pandemic. This will help people who have COVID-19 by providing blood donors and a biomedical engineering model.

What’s next after the project?

After completing and launching this project, we are going to make the biomedical engineering model more advanced and better-functioning. Additionally, we can include the precautions one must take based on the number of tests in the country. If there is a sharp increase in tests, we can further develop the model to update the website with more stringent protocols to follow during the lockdown. If adapted as a phone app, a sharp increase in testing could send users an alert to follow social distancing, wear masks, and stay safe. This update could also include a reminder about getting tested if you or any of your family members goes near a testing center with a high number of tests. These adaptations will allow this COVID-19 tracker to positively affect users and help them stay safe during the pandemic. As the software continues to update, we plan on including more visualizations including: number of positive cases over time, number of fatalities over time, and international travel over time.

Reference links we used for our product include:

High Tech Solutions

https://www.youtube.com/embed/TJ3-rgoKrs4 https://www.youtube.com/embed/GF_L-oxvdC0 https://www.youtube.com/embed/xc2tO8W4YiU https://www.youtube.com/embed/r7Ybn6qtpwE https://www.youtube.com/embed/y_6a1OohgyI

Covid-19 Resources

https://www.cdc.gov/coronavirus/2019-nCoV/index.html https://www.cdc.gov/coronavirus/2019-nCoV/index.html https://www.hhs.gov/coronavirus/community-based-testing-sites/index.html https://www.hhs.gov/coronavirus/community-based-testing-sites/index.html https://www.hhs.gov/answers/medicare-and-medicaid/where-can-i-find-a-doctor-that-accepts-medicare-medicaid/index.html http://emergency-rooms.find-near-me.info/ https://www.hhs.gov/answers/medicare-and-medicaid/where-can-i-find-a-doctor-that-accepts-medicare-medicaid/index.html

Data for backend code: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013652/references#dataAndAnalyses

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