With increased importance placed on personalized medicine and precision therapy in the biopharmaceutical industry, RNA-based therapeutics have become more relevant. Therefore, we want to use this method to further personalised medicine.
What it does
Our code creates transcription factor binding sites from binding motifs, and synthesizes ASOs to target top binding sites/sequences.
How we built it
Using JASPAR transcription factor motifs
Challenges we ran into
Creating a database of TFs and their motifs
Accomplishments that we're proud of
Incorporation of JASPAR motifs into R
What we learned
ASOs have not been shown to be used with DNA, therefore, this will be a new approach
What's next for ASO Targets
To create ASOs for all TFs to increase potential drug options
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